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The Stroke Research group

 

Christian Blomstrand Christian Blomstrand, Professor
Principal investigator for clinical stroke studies.
Tel: 46 31-3421400, Fax: 46 31-3422467
E-mail: christian.blomstrand@neuro.gu.se

 

 

 

Christina Jern Christina Jern, Professor
Principal investigator for clinical studies focusing hemostasis and genetics as well as experimental studies.
Tel: 46 31-3435720, Fax: 46 31-3422467
E-mail: christina.jern@neuro.gu.se

 

 

Katarina Jood Katarina Jood, PhD, MD
Co-Principal investigator for SAHLSIS/clinical stroke studies.
Tel: 46 31-3429052, Fax: 46 31-3422467
E-mail: katarina.jood@neuro.gu.se

 

 

 

Stroke is a complex disease with a considerable variation in pathophysiology, clinical presentation, treatment, consequences, and prognosis. In order to develop new and more effective preventive and therapeutic strategies, there is need for an increased knowledge of the risk factors and the physiological mechanisms that lead to stroke, as well as of factors of importance for recovery/ progression after stroke. The Stroke research group has a multidisciplinary competence including neurology, clinical genetics, molecular biology, occupational therapy, and psychology.

 

Our main projects:

The Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS):

A large case- control study of ischemic stroke before 70 years of age. Great emphasis has been on careful clinical characterization of cases including ischemic stroke subtypes. In this project risk factors for stroke are investigated with focus on genetics, hemostasis, and inflammation.

Co-workers:
Sandra Olsson, PhD, MSc
Ellen Hanson, MSc, PhD student
Annie Pedersen, MD
Tara Stanne, PhD, MSc
 

SAHLSIS-Cognition (SAHLSIS-COG)

A longitudinal study of the participants in SAHLSIS including a comprehensive follow-up after 7 years. In this project factors of importance for recovery/ progression are investigated. Cognition and progression of white matter lesions are in focus. Cognition is studied in collaboration with Hans Samuelson and Jo Viken. The impact on spouses coping is studied in collaboration with Gunilla Forsberg- Wärleby.

Co-workers:
Petra Redfors, MD, PhD student
Lukas Holmegaard, MD, PhD student
Ingrid Eriksson, Research Nurse
Jenny Ödquist Pettersson, Nurse
Christer Jensen, MD, Neuroradiologist

 

Experimental studies

Hypothesis generated from our clinical studies are tested by experimental approaches. At present we are investigating mechanisms behind our findings on fibrinolytic gene polymorphisms in SAHLSIS by studying regulation of tPA and PAI-1 expression in neuronal glial cells. Focus of this project is on functional characterization of polymorphisms.

Co-worker:
Karin Hultman, PhD, MSc
Martina Olsson, student
 

Occupational performance and consequences of stroke for the patient and his/her family

Studies on the patients’ ability performing everyday life activities are done in co-operation among others the SAHLSIS-COG and the Stroke Forum. Stroke affects also informal caregivers and the possibilities of participation in the society. The impact on the spouses concerning daily activities, participation, life satisfaction, health and coping is studied in a short- as well as in a long-term perspective. Focus is also on the impact on the patients’ health-related quality of life, use and impact of everyday technology. Other focuses are longterm cognitive and emotional consequences, participation and coping after mild stroke. Both qualitative and quantitative methods are used.

Co-workers:
Gunilla Gosman-Hedström, PhD, Reg. Ocup. Ther.
Lisbeth Claesson, PhD, Reg. Ocup. Ther.
Gunilla Forsberg-Wärleby, PhD, Reg. Occup. Ther.
Gunnel Carlsson, PhD, Reg. Occup. Ther.

 

Studies on stroke rehabilitation

In collaboration with national Stroke Research Institute, Melbourne, Australia we conduct a large study on early mobilisation and more intense training after stroke. Particular focus is kept on cognitive and emotional aspects after stroke. A study of intensity of training in rehabilitation units I Western Region of Sweden is planned. Attitudes as regards mobilisation and training will be studied by structured interviews of different professionals in stroke rehabilitation units.

Co-worker:
Thomas Lindén, PhD, MD

 

Studies on awareness and neglect phenomena

Virtual reality is adopted as a means to study hemispatial neglect and methods for training and motivation. fMRI studies are planned for further elucidation of training effects. Collaborations are tight with the Culture and Brain Health project within CBR (C. Blomstrand). Studies of long-term impact of ischemic stroke on cognition with special focus on awareness and neglect are done in collaboration with others in the SAHLSIS-COG.

Co-workers:
Hans Samuelsson, PhD, Psychologist
Jurgen Broeren, PhD, Reg. Occup.Ther
Jo Viken, PhD student
Henrik Olofsson, Psychologist

Sidansvarig: Katinka Almrén|Sidan uppdaterades: 2012-04-18
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