Joakim Ek

Elevated circulating adiponectin levels do not prevent anxiety-like behavior in a PCOS-like mouse

Manisha Samad, C. Joakim Ek, Stina Börchers, Jean-Philippe Krieger, Elisabet Stener-Victorin, Karolina P Skibicka, Ingrid Wernstedt Asterholm, Anna Benrick
SCIENTIFIC REPORTS - 2024

Proteomics identifies lipocalin-2 in neonatal inflammation associated with cerebrovascular alteration in mice and preterm

infants

Giacomo Gravina, Maryam Ardalan, Tetyana Chumak, Anders K. Nilsson, C. Joakim Ek, H. Danielsson, Pernilla Svedin, Milos Pekny, Marcela Pekna, Karin Sävman, Ann Hellström, Carina Mallard
iScience - 2023

Two different isoforms of osteopontin modulate myelination and axonal

integrity

Gisela M A Nilsson, Amin Mottahedin, Aura Zelco, V. M. Lauschke, C. Joakim Ek, Juan Song, Maryam Ardalan, Sha Hua, Xiaoli Zhang, Carina Mallard, Henrik Hagberg, J. W. Leavenworth, Xiaoyang Wang
Faseb Bioadvances - 2023

Alpha1-antitrypsin protects the immature mouse brain following hypoxic-ischemic

injury

Shan Zhang, W. D. Li, Y. R. Xu, Tao Li, C. Joakim Ek, X. L. Zhang, Yafeng Wang, J. Song, Changlian Zhu, Xiaoyang Wang
Frontiers in Cellular Neuroscience - 2023

The Alpha 7 Nicotinic Acetylcholine Receptor Does Not Affect Neonatal Brain

Injury

Maria Hammarlund, C. Joakim Ek, Sukaina Akar, Alma Karlsson, Bagmi Pattanaik, Filip Mjörnstedt, Pernilla Svedin, Maryam Ardalan, Eridan Rocha-Ferreira, Carina Mallard, Maria E Johansson
Biomedicines - 2022

Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal

rats

Juan Song, Gisela M A Nilsson, Y. R. Xu, Aura Zelco, Eridan Rocha-Ferreira, Yafeng Wang, X. L. Zhang, Shan Zhang, C. Joakim Ek, Henrik Hagberg, Changlian Zhu, Xiaoyang Wang
Journal of Cerebral Blood Flow and Metabolism - 2022

Microbial and human transcriptome in vaginal fluid at midgestation: Association with spontaneous preterm

delivery.

Tove Wikström, Sanna Abrahamsson, Johan Bengtsson-Palme, C. Joakim Ek, Pihla Kuusela, Elham Rekabdar, Peter Lindgren, Ulla-Britt Wennerholm, Bo Jacobsson, Lil Valentin, Henrik Hagberg
Clinical and translational medicine - 2022

Maternal n-3 Polyunsaturated Fatty Acid Enriched Diet Commands Fatty Acid Composition in Postnatal Brain and Protects from Neonatal Arterial Focal

Stroke

Tetyana Chumak, M. J. Lecuyer, Anders K. Nilsson, J. Faustino, Maryam Ardalan, Pernilla Svedin, Ulrika Sjöbom, C. Joakim Ek, A. Obenaus, Z. S. Vexler, Carina Mallard
Translational Stroke Research - 2022

Adipose Tissue-Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor

Growth.

Peter Micallef, Yanling Wu, Marco Bauzá-Thorbrügge, Belén Chanclón, Milica Vujičić, Eduard Peris, C. Joakim Ek, Ingrid Wernstedt Asterholm
International journal of molecular sciences - 2021

Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and

NETosis

A. Rayasam, A. Jullienne, Tetyana Chumak, J. Faustino, J. Szu, M. Hamer, C. Joakim Ek, Carina Mallard, A. Obenaus, Z. S. Vexler
Journal of Cerebral Blood Flow and Metabolism - 2021

Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage

Model

E. Axel Andersson, Eridan Rocha-Ferreira, Henrik Hagberg, Carina Mallard, C. Joakim Ek
Cells - 2021

Circulating tight-junction proteins are potential biomarkers for blood-brain barrier function in a model of neonatal hypoxic/ischemic brain

injury

E. Axel Andersson, Carina Mallard, C. Joakim Ek
Fluids and Barriers of the CNS - 2021

Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis-Potentiated Hypoxic-Ischemic Brain

Injury

Jacqueline Lai, Pernilla Svedin, C. Joakim Ek, Amin Mottahedin, Xiaoyang Wang, O. Levy, A. Currie, T. Strunk, Carina Mallard
Antimicrobial Agents and Chemotherapy - 2020

A Model of Germinal Matrix Hemorrhage in Preterm Rat

Pups.

Masako Jinnai, Gabriella Koning, Gagandeep Singh-Mallah, Andrea Jonsdotter, Anna-Lena Leverin, Pernilla Svedin, Syam Nair, Satoru Takeda, Xiaoyang Wang, Carina Mallard, C. Joakim Ek, Eridan Rocha-Ferreira, Henrik Hagberg
Frontiers in cellular neuroscience - 2020

The molecular anatomy and functions of the choroid plexus in healthy and diseased

brain

I. Kratzer, C. Joakim Ek, H. Stolp
Biochimica et Biophysica Acta - Biomembranes - 2020

Staphylococcus epidermidis Sensitizes Perinatal Hypoxic-Ischemic Brain Injury in Male but Not Female

Mice

Giacomo Gravina, Pernilla Svedin, Maryam Ardalan, O. Levy, C. Joakim Ek, Carina Mallard, Jacqueline Lai
Frontiers in Immunology - 2020

N-acetylcysteine inhibits bacterial lipopeptide-mediated neutrophil transmigration through the choroid plexus in the developing

brain

Amin Mottahedin, S. Blondel, C. Joakim Ek, Anna-Lena Leverin, Pernilla Svedin, Henrik Hagberg, Carina Mallard, J. F. Ghersi-Egea, N. Strazielle
Acta Neuropathologica Communications - 2020

Choroid plexus transcriptome and ultrastructure analysis reveals a TLR2-specific chemotaxis signature and cytoskeleton remodeling in leukocyte

trafficking

Amin Mottahedin, C. Joakim Ek, Katarina Truvé, Henrik Hagberg, Carina Mallard
Brain Behavior and Immunity - 2019

Magnesium induces preconditioning of the neonatal brain via profound mitochondrial

protection.

Gabriella Koning, Anna-Lena Leverin, Syam Nair, Leslie Schwendimann, C. Joakim Ek, Ylva Carlsson, Pierre Gressens, Claire Thornton, Xiaoyang Wang, Carina Mallard, Henrik Hagberg
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 2019

Dysmaturation of Somatostatin Interneurons Following Umbilical Cord Occlusion in Preterm Fetal

Sheep

Maryam Ardalan, Pernilla Svedin, A. A. Baburamani, V. G. Supramaniam, C. Joakim Ek, Henrik Hagberg, Carina Mallard
Frontiers in Physiology - 2019

Peripheral myeloid cells contribute to brain injury in male neonatal

mice

Peter L P Smith, Amin Mottahedin, Pernilla Svedin, Carl-Johan Mohn, Henrik Hagberg, C. Joakim Ek, Carina Mallard
Journal of Neuroinflammation - 2018

The myth of the immature barrier systems in the developing brain: role in perinatal brain

injury

Carina Mallard, C. Joakim Ek, Z. S. Vexler
Journal of Physiology-London - 2018

Serum concentrations of the axonal injury marker neurofilament light protein are not influenced by blood-brain barrier

permeability

Marie Kalm, Martina Boström, Åsa P Sandelius, Yohanna Eriksson, C. Joakim Ek, Kaj Blennow, Thomas Björk-Eriksson, Henrik Zetterberg
Brain Research - 2017

Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing

brain

Amin Mottahedin, Pernilla Svedin, Syam Nair, Carl-Johan Mohn, Xiaoyang Wang, Henrik Hagberg, C. Joakim Ek, Carina Mallard
Journal of Cerebral Blood Flow and Metabolism - 2017

γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in

mice

Xiaoli Zhang, Eridan Rocha-Ferreira, Tao Li, Regina Vontell, Darakhshan Jabin, Sha Hua, Kai Zhou, Arshed Nazmi, Anna-Maj Albertsson, Kristina Sobotka, C. Joakim Ek, Claire Thornton, Henrik Hagberg, Carina Mallard, Jianmei W. Leavenworth, Changlian Zhu, Xiaoyang Wang
Journal of Neuroinflammation - 2017

Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative

Disorders

Amin Mottahedin, Maryam Ardalan, Tetyana Chumak, Ilse Riebe, C. Joakim Ek, Carina Mallard
Frontiers in Cellular Neuroscience - 2017

TLR2-mediated leukocyte trafficking to the developing

brain.

Amin Mottahedin, Peter L P Smith, Henrik Hagberg, C. Joakim Ek, Carina Mallard
Journal of leukocyte biology - 2017

Immune responses in perinatal brain

injury.

Jacqueline Lai, Eridan Rocha-Ferreira, Xiaoyang Wang, C. Joakim Ek, Henrik Hagberg, Carina Mallard
Brain, behavior, and immunity - 2017

Radiation induces progenitor cell death, microglia activation, and blood-brain barrier damage in the juvenile rat

cerebellum

K. Zhou, Martina Boström, C. Joakim Ek, T. Li, C. C. Xie, Y. R. Xu, Y. Y. Sun, K. Blomgren, C. L. Zhu
Scientific Reports - 2017

GSK3β inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3

signalling

Barbara D'angelo, C. Joakim Ek, Yanyan Sun, Changlian Zhu, Mats Sandberg, Carina Mallard
Neuropharmacology - 2016

The blood-tendon barrier: Identification and characterisation of a novel tissue barrier in tendon blood

vessels

C. Lehner, R. Gehwolf, C. Joakim Ek, S. Korntner, H. Bauer, H. C. Bauer, A. Traweger, H. Tempfer
European Cells and Materials - 2016

Delayed astrocytic contact with cerebral blood vessels in FGF-2 deficient mice does not compromise permeability properties at the developing blood-brain

barrier

N. R. Saunders, K. M. Dziegielewska, K. Unsicker, C. Joakim Ek
Developmental Neurobiology - 2016

Melatonin reduces excitotoxic blood-brain barrier breakdown in neonatal

rats

R. Moretti, A. Zanin, J. Pansiot, D. Spiri, L. Manganozzi, I. Kratzer, G. Favero, A. Vasiljevic, V. E. Rinaldi, I. Pic, D. Massano, I. D'Agostino, Ana A Baburamani, M. A. La Rocca, L. F. Rodella, R. Rezzani, C. Joakim Ek, N. Strazielle, J. F. Ghersi-Egea, P. Gressens, L. Titomanlio
Neuroscience - 2015

Staphylococcus epidermidis Bacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent

Pathways

Dan Bi, Lili Qiao, Ilana Bergelson, C. Joakim Ek, Luqi Duan, Xiaoli Zhang, Anna-Maj Albertsson, Matthew Pettengill, Kenny Kronforst, Jana Ninkovic, Donald Goldmann, Anders Janzon, Henrik Hagberg, Xiaoyang Wang, Carina Mallard, Ofer Levy
The Journal of infectious diseases - 2015

Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral

hypoxia-ischemia

C. Joakim Ek, Barbara D'angelo, Ana A Baburamani, C. Lehner, Anna-Lena Leverin, Peter L P Smith, Holger Nilsson, Pernilla Svedin, Henrik Hagberg, Carina Mallard
Journal of Cerebral Blood Flow and Metabolism - 2015

Expression of tight junction proteins and transporters for xenobiotic metabolism at the blood-CSF barrier during development in the nonhuman primate (P.

hamadryas)

C. Joakim Ek, Barbara D'angelo, C. Lehner, P. Nathanielsz, C. Li, Carina Mallard
Reproductive Toxicology - 2015

Transcriptomal changes and functional annotation of the developing non-human primate choroid

plexus

C. Joakim Ek, P. Nathanielsz, C. Li, Carina Mallard
Frontiers in Neuroscience - 2015

Innate defence regulator peptide 1018 protects against perinatal brain

injury.

Hayde Bolouri, Karin Sävman, Wei Wang, Anitha Thomas, Norbert Maurer, Edie Dullaghan, Christopher D Fjell, C. Joakim Ek, Henrik Hagberg, Robert E W Hancock, Kelly Brown, Carina Mallard
Annals of neurology - 2014

Perinatal Hypoxia-Ischemia Reduces alpha 7 Nicotinic Receptor Expression and Selective alpha 7 Nicotinic Receptor Stimulation Suppresses Inflammation and Promotes Microglial Mox

Phenotype

Sansan Hua, C. Joakim Ek, Carina Mallard, Maria E Johansson
Biomed Research International - 2014

Targeting the vasculature for cerebroprotection in the immature

brain.

Henrik Hagberg, C. Joakim Ek
Experimental neurology - 2014

Age-Dependent Transcriptome and Proteome Following Transection of Neonatal Spinal Cord of Monodelphis domestica (South American Grey Short-Tailed

Opossum)

N. R. Saunders, N. M. Noor, K. M. Dziegielewska, B. J. Wheaton, S. A. Liddelow, D. L. Steer, C. Joakim Ek, M. D. Habgood, M. J. Wakefield, H. Lindsay, J. Truettner, R. D. Miller, A. I. Smith, W. D. Dietrich
Plos One - 2014

Expression of the Nrf2-system at the blood-CSF barrier is modulated by neonatal inflammation and

hypoxia-ischemia

Barbara D'angelo, C. Joakim Ek, Mats Sandberg, Carina Mallard
Journal of Inherited Metabolic Disease - 2013

Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural

Approach

S. A. Liddelow, K. M. Dziegielewska, C. Joakim Ek, M. D. Habgood, H. Bauer, H. C. Bauer, H. Lindsay, M. J. Wakefield, N. Strazielle, I. Kratzer, K. Mollgard, J. F. Ghersi-Egea, N. R. Saunders
Plos One - 2013

Regulation of Toll-Like Receptors in the Choroid Plexus in the Immature Brain After Systemic Inflammatory

Stimuli

Linnea Stridh, C. Joakim Ek, Xiaoyang Wang, Holger Nilsson, Carina Mallard
Translational Stroke Research - 2013

Vulnerability of the developing brain to hypoxic-ischemic damage: Contribution of the cerebral vasculature to injury and

repair?

Ana A Baburamani, C. Joakim Ek, David W. Walker, Margie Castillo-Melendez
Frontiers in Physiology - 2012

Barriers in the developing brain and

Neurotoxicology

C. Joakim Ek, K. M. Dziegielewska, M. D. Habgood, N. R. Saunders
Neurotoxicology - 2012

Pathological Changes in the White Matter after Spinal Contusion Injury in the

Rat

C. Joakim Ek, M. D. Habgood, R. Dennis, K. M. Dziegielewska, Carina Mallard, B. Wheaton, N. R. Saunders
Plos One - 2012

Joakim Ek

Universitetslektor

Publikationer