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Anna Benrick
Forskare
Sektionen förOm Anna Benrick
Vi fokuserar på kopplingen mellan överskott av manligt könshormon, så kallade androgener, och utvecklingen av reproduktionsstörningar, fetma och typ 2-diabetes hos kvinnor. Vårt övergripande mål är att identifiera bakomliggande mekanismer och undersöka nya behandlingsmetoder som förbättrar eller skyddar mot utvecklingen av diabetes och infertilitet.
Min forskningslinje har utvecklats från mer än 10 års erfarenhet av fysiologistudier inom endokrinologi, metabolism och reproduktion. År 2010 återvände jag till Göteborgs universitet efter en postdoc vid Garvan Institute for Medical Research, finansierat av Vetenskapsrådet.
År 2015 startade jag min egen grupp och forskningslinje. Jag är för närvarande bihandledare för tre doktorander och mitt labb tar regelbundet emot studenter som bidrar till våra forskningsprojekt.
Forskargrupp
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Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with
PCOS
Elisabet Stener-Victorin, Gustaw Eriksson, Man Mohan Shrestha, Valentina Rodriguez Paris, Haojiang Lu, Jasmine Banks, Manisha Samad, Charlene Perian, Baptiste Jude, Viktor Engman, Roberto Boi, Emma Nilsson, Charlotte Ling, Jenny Nyström, Ingrid Wernstedt Asterholm, Nigel Turner, Johanna Lanner, Anna Benrick
ELIFE - 2024 -
Elevated circulating adiponectin levels do not prevent anxiety-like behavior in a PCOS-like mouse
model
Manisha Samad, C. Joakim Ek, Stina Börchers, Jean-Philippe Krieger, Elisabet Stener-Victorin, Karolina P Skibicka, Ingrid Wernstedt Asterholm, Anna Benrick
SCIENTIFIC REPORTS - 2024 -
Adiponectin stimulates Sca1+CD34--adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose
tissue.
Marco Bauzá-Thorbrügge, Milica Vujičić, Belén Chanclón, Vilborg Palsdottir, Nicolas J Pillon, Anna Benrick, Ingrid Wernstedt Asterholm
Metabolism: clinical and experimental - 2023 -
NRF2 is essential for adaptative browning of white
adipocytes.
Marco Bauzá-Thorbrügge, Eduard Peris Franquet, Shabnam Zamani, Peter Micallef, Alexandra Paul, Stefano Bartesaghi, Anna Benrick, Ingrid Wernstedt Asterholm
Redox biology - 2023 -
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon
secretion
Nikhil Gandasi, Rui Gao, Lakshmi Kothegala, Abigail Pearce, Cristiano Santos, Samuel Acreman, Davide Basco, Anna Benrick, Margarita V. Chibalina, Anne Clark, Claudia Guida, Matthew Harris, Paul R. V. Johnson, Jakob G. Knudsen, Jinfang Ma, Caroline Miranda, Makoto Shigeto, Andrei I. Tarasov, Ho Yan Yeung, Bernard Thorens, Ingrid Wernstedt Asterholm, Quan Zhang, Reshma Ramracheya, Graham Ladds, Patrik Rorsman
DIABETOLOGIA - 2023 -
Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary
syndrome
S. Risal, C. R. Li, Q. Luo, R. Fornes, H. J. Lu, G. Eriksson, M. Manti, Claes Ohlsson, E. Lindgren, N. Crisosto, M. Maliqueo, B. Echiburu, S. Recabarren, T. S. Petermann, Anna Benrick, N. Brusselaers, J. Qiao, Q. L. Deng, E. Stener-Victorin
Cell Reports Medicine - 2023 -
Adiponectin Deficiency Alters Placenta Function but Does Not Affect Fetal Growth in
Mice
Man Mohan Shrestha, Sanne Wermelin, E. Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
International Journal of Molecular Sciences - 2022 -
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1
diabetes.
Angela Kim, Jakob G Knudsen, Joseph C Madara, Anna Benrick, Thomas G Hill, Lina Abdul Kadir, Joely A Kellard, Lisa J. Mellander, Caroline Miranda, Haopeng Lin, Timothy James, Kinga Suba, Aliya F Spigelman, Yanling Wu, Patrick E MacDonald, Ingrid Wernstedt Asterholm, Tore Magnussen, Mikkel Christensen, Tina Vilsbøll, Victoria Salem, Filip K Knop, Patrik Rorsman, Bradford B Lowell, Linford Jb Briant
eLife - 2021 -
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and
epigenetics
C. Davegardh, J. Sall, Anna Benrick, C. Broholm, P. Volkov, A. Perfilyev, T. I. Henriksen, Yanling Wu, L. Hjort, C. Brons, O. Hansson, M. Pedersen, J. U. Wurthner, K. Pfeffer, E. Nilsson, A. Vaag, E. Stener-Victorin, K. Pircs, C. Scheele, C. Ling
Nature Communications - 2021 -
Maternal adiponectin prevents visceral adiposity and adipocyte hypertrophy in prenatal androgenized female
mice
Yanling Wu, Belén Chanclón, Peter Micallef, E. Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
FASEB Journal - 2021 -
Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety
disorders
S. Risal, M. Manti, H. J. Lu, R. Fornes, H. Larsson, Anna Benrick, Q. L. Deng, C. E. Cesta, M. A. Rosenqvist, E. Stener-Victorin
Translational Psychiatry - 2021 -
Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice
offspring.
Maria Manti, Romina Fornes, Gianluigi Pironti, Sarah McCann Haworth, Zhuge Zhengbing, Anna Benrick, Mattias Carlström, Daniel Andersson, Elisabet Stener-Victorin
Cardiovascular research - 2020 -
Skeletal Muscle Immunometabolism in Women With Polycystic Ovary Syndrome: A
Meta-Analysis
M. Manti, E. Stener-Victorin, Anna Benrick
Frontiers in Physiology - 2020 -
Electroacupuncture mimics exercise-induced changes in skeletal muscle gene expression in polycystic ovary syndrome
women.
Anna Benrick, Nicolas J Pillon, Emma Nilsson, Eva Lindgren, Anna Krook, Charlotte Ling, Elisabet Stener-Victorin
The Journal of clinical endocrinology and metabolism - 2020 -
Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female
mice
M. Manti, H. P. Pui, S. Edstrom, S. Risal, H. J. Lu, E. Lindgren, Claes Ohlsson, Elisabeth Jerlhag, Anna Benrick, Q. L. Deng, E. Stener-Victorin
FASEB Journal - 2020 -
Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic
delta-cells.
Elisa Vergari, Geoffrey Denwood, Albert Salehi, Quan Zhang, Julie Adam, Ahmed Alrifaiy, Ingrid Wernstedt Asterholm, Anna Benrick, Margarita V Chibalina, Lena Eliasson, Claudia Guida, Thomas G Hill, Alexander Hamilton, Reshma Ramracheya, Frank Reimann, Nils J G Rorsman, Ioannis Spilliotis, Andrei I Tarasov, Jonathan N Walker, Patrik Rorsman, Linford J B Briant
Nature metabolism - 2020 -
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary
Syndrome
E. Stener-Victorin, V. Padmanabhan, K. A. Walters, R. E. Campbell, Anna Benrick, P. Giacobini, D. A. Dumesic, D. H. Abbott
Endocrine Reviews - 2020 -
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary
syndrome.
Sanjiv Risal, Yu Pei, Haojiang Lu, Maria Manti, Romina Fornes, Han-Pin Pui, Zhiyi Zhao, Julie Massart, Claes Ohlsson, Eva Lindgren, Nicolas Crisosto, Manuel Maliqueo, Barbara Echiburú, Amanda Ladrón de Guevara, Teresa Sir-Petermann, Henrik Larsson, Mina A Rosenqvist, Carolyn E Cesta, Anna Benrick, Qiaolin Deng, Elisabet Stener-Victorin
Nature medicine - 2019 -
Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal
liver
R. Fornes, M. Manti, X. J. Qi, Egor Vorontsov, Carina Sihlbom, Jenny Nyström, Elisabeth Jerlhag, M. Maliqueo, A. L. Hirschberg, M. Carlstrom, Anna Benrick, E. Stener-Victorin
International Journal of Obesity - 2019 -
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin
secretion
E. Vergari, J. G. Knudsen, R. Ramracheya, Albert Salehi, Q. Zhang, J. Adam, Ingrid Wernstedt Asterholm, Anna Benrick, L. J. B. Briant, M. V. Chibalina, F. M. Gribble, A. Hamilton, B. Hastoy, F. Reimann, N. J. G. Rorsman, II Spiliotis,, A. Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Nature Communications - 2019 -
Transcriptional and Epigenetic Changes Influencing Skeletal Muscle Metabolism in Women With Polycystic Ovary
Syndrome
E. Nilsson, Anna Benrick, Milana Kokosar, A. Krook, E. Lindgren, T. Kallman, M. M. Martis, K. Hojlund, C. Ling, E. Stener-Victorin
Journal of Clinical Endocrinology & Metabolism - 2018 -
Maternal androgen excess and obesity induce sexually dimorphic anxiety-like behavior in the
offspring
M. Manti, R. Fornes, X. J. Qi, E. Folmerz, A. L. Hirschberg, T. D. Barbosa, M. Maliqueo, Anna Benrick, E. Stener-Victorin
Faseb Journal - 2018 -
A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary
Syndrome
Milana Kokosar, Anna Benrick, A. Perfilyev, E. Nilsson, T Källman, Claes Ohlsson, C. Ling, E. Stener-Victorin
Scientific Reports - 2018 -
The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese
dams
R. Fornes, M. Maliqueo, Min Hu, Laila Hadi, J. M. Jimenez-Andrade, Kerstin Ebefors, Jenny Nyström, F. Labrie, T. Jansson, Anna Benrick, E. Stener-Victorin
Scientific Reports - 2017 -
Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to
electroacupuncture
Anna Benrick, Milana Kokosar, Min Hu, Mårten Larsson, M. Maliqueo, R. R. Marcondes, M. Soligo, V. Protto, Elisabeth Jerlhag, Antonina Sazonova, Carl Johan Behre, K. Hojlund, P. Thoren, E. Stener-Victorin
Faseb Journal - 2017 -
Adiponectin protects against development of metabolic disturbances in a PCOS mouse
model
Anna Benrick, Belén Chanclón, Peter Micallef, Yanling Wu, Laila Hadi, J. M. Shelton, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm
Proceedings of the National Academy of Sciences of the United States of America - 2017 -
Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary
syndrome.
Rodrigo R Marcondes, Manuel Maliqueo, Romina Fornes, Anna Benrick, Min Hu, Niklas Ivarsson, Mattias Carlström, Samuel W Cushman, Karin G Stenkula, Gustavo A R Maciel, Elisabet Stener-Victorin
Molecular and cellular endocrinology - 2017 -
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary
syndrome.
Manuel Maliqueo, Anna Benrick, Rodrigo Rodrigues Marcondes, Julia Johansson, Miao Sun, Elisabet Stener-Victorin
Experimental physiology - 2017 -
Maternal testosterone and placental function: Effect of electroacupuncture on placental expression of angiogenic markers and fetal
growth
R. Fornes, M. Hu, M. Maliqueo, Milana Kokosar, Anna Benrick, D. Carr, Håkan Billig, T. Jansson, L. Manni, E. Stener-Victorin
Molecular and Cellular Endocrinology - 2016 -
Changes in HbA(1c) and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to
electroacupuncture
Elisabet Stener-Victorin, M. Maliqueo, M. Soligo, V. Protto, L. Manni, Elisabeth Jerlhag, Milana Kokosar, Antonina Sazonova, Carl Johan Behre, Marcus Lind, Claes Ohlsson, K. Hojlund, Anna Benrick
Obesity Science & Practice - 2016 -
Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary
Syndrome
Milana Kokosar, Anna Benrick, A. Perfilyev, R. Fornes, E. Nilsson, M. Maliqueo, Carl Johan Behre, Antonina Sazonova, Claes Ohlsson, C. Ling, Elisabet Stener-Victorin
Scientific Reports - 2016 -
Erratum: Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary
Syndrome.
Milana Kokosar, Anna Benrick, Alexander Perfilyev, Romina Fornes, Emma Nilsson, Manuel Maliqueo, Carl Johan Behre, Antonina Sazonova, Claes Ohlsson, Charlotte Ling, Elisabet Stener-Victorin
Scientific reports - 2016 -
Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the
offspring.
Min Hu, Jennifer E. Richard, Manuel Maliqueo, Milana Kokosar, Romina Fornes, Anna Benrick, Thomas Jansson, Claes Ohlsson, Xiaoke Wu, Karolina P Skibicka, Elisabet Stener-Victorin
Proceedings of the National Academy of Sciences of the United States of America - 2015 -
Dietary polyunsaturated fatty acids increase survival and decrease bacterial load during septic S. aureus infection, and improve neutrophil function in
mice
Sara L Svahn, Louise Grahnemo, Vilborg Palsdottir, Intawat Nookaew, Karl Wendt, Britt G. Gabrielsson, Erik Scheele, Anna Benrick, Niklas Andersson, Staffan Nilsson, Maria E Johansson, John-Olov Jansson
Infection and Immunity - 2015 -
Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or beta-adrenergic action in a female hyperandrogenic rat model of polycystic ovary
syndrome
Manuel Maliqueo, Anna Benrick, Asif Alvi, Julia Johansson, Miao Sun, F. Labrie, Claes Ohlsson, Elisabet Stener-Victorin
Molecular and Cellular Endocrinology - 2015 -
Placental STAT3 signaling is activated in women with polycystic ovary
syndrome
Manuel Maliqueo, I. Sundstrom Poromaa, E. Vanky, R. Fornes, Anna Benrick, H. Akerud, S. Stridsklev, F. Labrie, T. Jansson, Elisabet Stener-Victorin
Human reproduction (Oxford, England) - 2015 -
Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass
spectrometry.
Maria E. Nilsson, Liesbeth Vandenput, Åsa Tivesten, Anna-Karin Norlén, Marie K Lagerquist, Sara H Windahl, Anna E Börjesson, Helen H. Farman, Matti Poutanen, Anna Benrick, Manuel Maliqueo, Elisabet Stener-Victorin, Henrik Ryberg, Claes Ohlsson
Endocrinology - 2015 -
Enhanced insulin sensitivity and acute regulation of metabolic genes and signaling pathways after a single electrical or manual acupuncture session in female insulin-resistant
rats.
Anna Benrick, Manuel Maliqueo, Julia Johansson, Miao Sun, Xiaoke Wu, Louise Mannerås Holm, Elisabet Stener-Victorin
Acta Diabetologica - 2014 -
Gene expression in subcutaneous adipose tissue differs in women with polycystic ovary syndrome and controls matched pair-wise for age, body weight, and body mass
index.
Louise Mannerås Holm, Anna Benrick, Elisabet Stener-Victorin
Adipocyte - 2014 -
Rodent Models of Polycystic Ovary Syndrome: Phenotypic Presentation, Pathophysiology, and the Effects of Different
Interventions
Manuel Maliqueo, Anna Benrick, Elisabet Stener-Victorin
Seminars in Reproductive Medicine - 2014 -
Elevated interlukin-6 levels as a consequence, not the cause of obesity and insulin
resistance
Anna Benrick, Ingrid Wernstedt Asterholm
Interleukin-6: Genetics, Clinical Applications and Role in Disease - 2013 -
Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary
Syndrome
Anna Benrick, Manuel Maliqueo, Miao Sun, J. A. Villanueva, Y. Feng, Claes Ohlsson, A. J. Duleba, Elisabet Stener-Victorin
Evidence-Based Complementary and Alternative Medicine - 2013 -
Interrelation between interleukin-1 (IL-1), IL-6 and body fat regulating circuits of the hypothalamic arcuate
nucleus.
Erik Schéle, Anna Benrick, Louise Grahnemo, Emil Egecioglu, Fredrik Anesten, Vilborg Palsdottir, John-Olov Jansson
Journal of neuroendocrinology - 2013 -
Continuous Administration of a P450 Aromatase Inhibitor Induces Polycystic Ovary Syndrome with a Metabolic and Endocrine Phenotype in Female Rats at Adult
Age
Manuel Maliqueo, M. Sun, Julia Johansson, Anna Benrick, F. Labrie, Henrik Svensson, Malin Lönn, A. J. Duleba, Elisabet Stener-Victorin
Endocrinology - 2013 -
Interleukin-6 mediates exercise-induced increase in insulin sensitivity in
mice.
Anna Benrick, Ville Wallenius, Ingrid Wernstedt Asterholm
Experimental physiology - 2012 -
Maternal androgen excess reduce placental and fetal weights, increase placental steroidogenesis and leads to long-term health effects in their female
offspring.
Miao Sun, Manuel Maliqueo, Anna Benrick, Julia Johansson, Linus Ruijin Shao, Lihui Hou, Thomas Jansson, Xiaoke Wu, Elisabet Stener-Victorin
American journal of physiology. Endocrinology and metabolism - 2012 -
Genetic Association and Gene Expression Analysis Identify FGFR1 as a New Susceptibility Gene for Human
Obesity.
Hong Jiao, Peter Arner, Suzanne L. Dickson, Hubert Vidal, Niklas Mejhert, Corneliu Henegar, Magdalena Taube, Caroline Hansson, Anke Hinney, Pilar Galan, Chantal Simon, Angela Silveira, Anna Benrick, John-Olov Jansson, Anne Bouloumié, Dominique Langin, Martine Laville, Cyrille Debard, Tomas Axelsson, Mikael Rydén, Juha Kere, Karin Dahlman-Wright, Anders Hamsten, Karine Clement, Ingrid Dahlman
The Journal of clinical endocrinology and metabolism - 2011 -
Central nervous system lipocalin-type prostaglandin D2-synthase is correlated with orexigenic neuropeptides, visceral adiposity and markers of the hypothalamic-pituitary-adrenal axis in obese
humans.
Erik Elias, Anna Benrick, Carl Johan Behre, Rolf Ekman, Henrik Zetterberg, Kaj Stenlöf, Ville Wallenius
Journal of neuroendocrinology - 2011 -
Mice chronically fed high-fat diet have increased mortality and disturbed immune response in
sepsis.
Louise Strandberg, Margareta Verdrengh, Maria Enge, Niklas Andersson, Sylvie Amu, Karin Önnheim, Anna Benrick, Mikael Brisslert, Johan Bylund, Maria Bokarewa, Staffan Nilsson, John-Olov Jansson
PloS one - 2009 -
Interleukin-6 gene knockout influences energy balance regulating peptides in the hypothalamic paraventricular and supraoptic
nuclei.
Anna Benrick, Erik Schéle, S B Pinnock, Ingrid Wernstedt Asterholm, Suzanne L. Dickson, Linda Karlsson-Lindahl, John-Olov Jansson
Journal of neuroendocrinology - 2009 -
Down-Regulation of Cilia-Localized IL-6R{alpha} by 17{beta}-Estradiol in Mouse and Human Fallopian
Tubes.
Linus Ruijin Shao, Magdalena Nutu, Linda Karlsson-Lindahl, Anna Benrick, Birgitta Weijdegård, Susanne Lager, Emil Egecioglu, Julia Fernandez-Rodriguez, Christina Gemzell-Danielsson, Claes Ohlsson, John-Olov Jansson, Håkan Billig
American journal of physiology. Cell physiology - 2009 -
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive
population.
Anna Benrick, Pernilla Jirholt, Ingrid Wernstedt, Maria Gustafsson, Juergen Scheller, Anna-Lena Eriksson, Jan Borén, Thomas Hedner, Claes Ohlsson, Torleif Härd, Stefan Rose-John, John-Olov Jansson
Regulatory peptides - 2008 -
Cytokines in Metabolic
Functions
Anna Benrick
2008 -
Mature-onset obesity in interleukin-1 receptor I knockout
mice.
Maria C García, Ingrid Wernstedt, Anna Berndtsson, Maria Enge, Michal Bell, Olof H. Hultgren, Michael Horn, Bo Ahrén, Sven Enerbäck, Claes Ohlsson, Ville Wallenius, John-Olov Jansson
Diabetes - 2006 -
Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient
mice.
Ingrid Wernstedt, Amanda Edgley, Anna Berndtsson, Jenny Fäldt, Göran Bergström, Ville Wallenius, John-Olov Jansson
American journal of physiology. Regulatory, integrative and comparative physiology - 2006 -
Leukemia inhibitory factor reduces body fat mass in ovariectomized
mice
John-Olov Jansson, Sofia Movérare-Skrtic, Anna Berndtsson, Ingrid Wernstedt, Hans Carlsten, Claes Ohlsson
Eur J Endocrinol - 2006 -
A common polymorphism in the interleukin-6 gene promoter is associated with
overweight
Ingrid Wernstedt, Anna-Lena Eriksson, Anna Berndtsson, J Hoffstedt, Stanko Skrtic, Thomas Hedner, Lillemor Mattsson Hultén, Olov Wiklund, Claes Ohlsson, John-Olov Jansson
Int J Obes Relat Metab Disord - 2004