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Regulation of Pancreatic Hormone Secretion


Forskargruppsledare: Patrik Rorsman

Följande information finns endast på engelska.

Type-2 diabetes is characterized by loss of insulin secretion from pancreatic β-cells. The reduced insulin secretion is further accompanied by defects in the release of the other islet hormones glucagon and somatostatin. The aim of our research is to explain how changes in the plasma glucose concentration, via islet cell electrical activity and increases in the cytoplasmic Ca2+-concentration, regulate exocytotic release of insulin as well as glucagon and somatostatin.

Our work involves a battery of cell physiological techniques to study secretion at the molecular, cellular and systemic levels. This requires sophisticated methodology to record the minute electrical currents flowing across biological membranes and secretion in individual cells at millisecond resolution. We also use optical techniques to monitor the movements of single secretory granules within the cell prior and during secretion.

Our studies will result in improved understanding of the fundamental processes that control pancreatic hormone secretion under physiological conditions and how they become disrupted in disease state with a view to develop new paradigms for the management and treatment of diabetes.

Photo of Patrik Rorsman

Patrik Rorsman

Forskargruppsledare
Professor

Kontakt
Tel: 031-786 6807 eller +44-1865-857348
E-post: patrik.rorsman@gu.se eller patrik.rorsman@drl.ox.ac.uk
Besöks- och postadresser

Gruppmedlemmar

Frances Ashcroft
Gästprofessor

Nikhil Gandasi
Forskare

Lakshmi Kothegala
Forskare

Lisa Mellander
Forskare

Ahmed Alrifaiy
Postdoktor

Massimo Muratore
Postdoktor

Joana Real
Postdoktor

Johan Tolö
Postdoktor

Belén Chanclón García
Postdoktor

Haiqiang Dou
Postdoktor

Caroline Miranda
Doktorand

Cristiano Santos
Doktorand

Forugh Vazirisani
Biomedicinsk analytiker

Myrvete Hoti
Ekonomiadministratör

Sidansvarig: Annie Sundling|Sidan uppdaterades: 2015-08-26
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