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Utvalda publikationer

 In total 15 500 citations, 7 000 since 2012, H-index 56, i10 index 125. Full list of publications - PubMed

Google Scholar citations



1. Wallenius V, Wallenius K, Ahrén B, Rudling M, Dickson SL, Ohlsson C, Jansson J-O. 2002 Interleukin-6 deficient mice develop mature-onset obesity. Nature Medicine 8:75-79.

The first article to show that endogenous IL-6, unexpectedly, exerts a tonic antiobesity effect in mature healthy mice via effects at the CNS level. Cited 1039 times, Google scholar 2017.



2. Wallenius K, Wallenius V, Sunter D, Dickson SL, Jansson J-O. 2002 Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochem Biophys Res Comm 293:560-565.

Follow up article showing that IL-6 decreases obesity via an effect on the brain. Cited 207 times, Google scholar 2017.



3. Stenlöf K; Wernstedt I, Fjällman T, Wallenius V, Wallenius K, Jansson J-O. 2003. Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects. J Clin Endocrinol Metab. 88:4579-4383.

IL-6 is found in larger concentrations in the CSF than in the serum indicating local production the CNS of healthy humans. Moreover, there were larger CSF IL-6 levels in lean individuals. Cited 113 times, Google scholar 2017.



4. Fäldt J, Wernstedt I, Fitzgerald SM, Wallenius K, Bergström G, Jansson J-O. 2004. Reduced exercise endurance in interleukin-6 deficient mice. Endocrinology 145:2680-2686.

The first study to show that endogenous IL-6, released to the blood from exercising muscle, is important for exercise effects. Cited 107 times, Google scholar 2017.



5. Wernstedt, I, Edgley A, Wallenius K, Fäldt J, Bergström G, Wallenius V, Jansson JO. 2006. Reduced stress- and cold-induced increase in energy expenditure in interleukin-6 deficient mice. Am J Physiol 291:R551-R557.

Endogenous IL-6 is important for thermogenesis by BAT, an effect that could contribute to IL-6 induced leanness. Cited 65 times, Google scholar 2017.



6. Garcia M, Wernstedt I, Berndtsson A, Enge M, Bell M, Hultgren O, Horn M, Ahren B, Enerbäck S, Ohlsson C, Wallenius V, Jansson J-O. 2006. Mature onset obesity in interleukin-1 receptor I (IL-1RI) knockout mice. Diabetes, 55:1205-1213.

Endogenous IL-1, like IL-6, seems to exert a consistent anti-obesity effect at the level of the CNS in mature healthy mice. Cited 143 times, Google scholar 2017.



7. Matthews VB, Allen TL, Risis S, Chan MHS, Henstridge DC, Watson N, Zaffino LA, Babb JR, Boon J, . Meikle PJ, Jowett JB, Watt MJ, Jansson JO, Bruce CR, Febbraio MA. 2010. Interleukin-6 deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia 53:2431-2441.

Confirms that endogenous IL-6 suppresses obesity in mice, and also shows that IL-6 promotes a healthy liver and insulin sensitivity. Cited 197 times, Google scholar 2017.



8. Sarwar N; Butterworth AS,...Jansson JO,....Harari O, Danesh J.2012. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 379:1205-1213.

An IL-6 system polymophism is associated with cardiometabolic disease.



9. Shirazi R, Palsdottir V, Collander J, Anesten F, Vogel H, Langlet F, Jaschke A, Schuermann A, Prevot V, Shao R, Jansson J-O, Skibicka KP. GLP-1 receptor stimulation induced suppression of food intake and body weight is mediated by central interleukin-1 and interleukin-6. Proc Natl Acad Sci, USA, 110:16199-16204.

Shows unexpectedly that GLP-1 analogues, one of very few pharmaceutical classes with antiobesity properties, act via IL-6 and IL-1 in the brain. Cited 64 times, Google scholar 2017.



10. Jansson JO, Pálsdóttir V. 2015. Brain IL-6 – Where amylin and GLP-1 antiobesity signaling congregate. Diabetes 64:1498-1499.

Sums up the role of IL-6 as mediator of the clinical anti-obesity effects by GLP-1 and amylin analogues.



11. Anesten F, Holt MK, Schéle E, Pálsdóttir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. 2016. Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.Am J Physiol 311:R115-R123.

Shows that there are functional IL-6 receptors on GLP-1 producing cells in the brainstem, raising the possibility that IL-6 regulates GLP-1 producing cells in the CNS. We have already observed regulation of IL-6 by GLP-1 in the brain (PNAS 2013).



12. Jansson JO, Palsdottir V, Hägg DA, Schéle E, Dickson SL, Anesten F, Bake T, Montelius M, Bellman J, Johansson ME, Cone RD, Drucker DJ, Wu J, Aleksic B, Törnqvist AE, Sjögren K, Gustafsson JÅ, Windahl SH, Ohlsson C.2018.Body weight homeostat that regulates fat mass independently of leptin in rats and mice.Proc.Natl.Acad.Sci USA, 115(2):427-432.

This article provides support for the existence of internal bathroom scales. The weight of the body is registered in the lower extremities. If the body weight tends to increase, a signal is sent to the brain to decrease food intake and keep the body weight constant. This newly published has got a lot of attention in media, for instance in Newsweek, New York Times and Swedish National Television (Landet Runt, Rapport). Almeteric Score 658, top 5% of science publications.



13. Ohlsson C, Hägg DA, Hammarhjelm F, Dallmau Gasull A, Bellman J, Windahl S, Palsdottir V, Jansson JO. Endocrinology The gravitostat regulates fat mass in obese male mice while leptin regulates fat mass in lean male mice. Endocrinology, en.2018-00307, https://doi.org/10.1210/en.2018-00307.

In this very recent article we demonstrate that the gravitostat regulates fat mass in obese mice while leptin regulates fat mass only in lean mice. We propose that activation of the gravitostat primarily protects against obesity (=anti-obesity signal) while low levels of leptin protects against undernutrition (=anti-fasting signal).
This is potentially a very important finding, given that the anti-obesity signal that can step for leptin has been sought for over 20 years (Ahima RS et al 1996 Nature 382:250-250).

 

 

Sidansvarig: Annie Sundling|Sidan uppdaterades: 2018-09-26
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