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Molecular Cognition

Principal Investigator: Petronella Kettunen

Current research in the Kettunen lab include:

  1. Molecular and cellular mechanisms of learning and memory
    We are studying the molecular and cellular events that underlie learning. To this end, we are using the zebrafish (Danio rerio) and combining transgenic and molecular methods, behavioral experiments, in vivo calcium imaging and optogenetics.

    The project FISHDOPA is funded by FP7/European commission via a Marie Skłodowska-Curie grant to Dr Marco A. Vindas. It is focusing on understanding the role of the dopaminergic system in reward learning in fish. The project is described in detail here: FISHDOPA

    We are also interested in human memory, memory testing and are associated with the Memory clinic in Mölndal, Sweden. Here, we are responsible for future genetic analysis of the patient material. In addition, Dr Kettunen is the co-director of the Center for Cognitive Medicine in Gothenburg, and organizes an annual PhD course in Learning and memory at University of Gothenburg.

  2. Pathways underlying memory impairments and neurodegeneration in Alzheimer’s disease
    We are interested in understanding how the Alzheimer’s disease-related peptide, amyloid-beta, is preventing memory formation in vivo. We are also studying the processes of amyloid-beta-mediated neurodegeneration and how these can be targeted for drug discovery. This project is supported by Sweden’s innovation agency VINNOVA.
  3. The role of microglia in Alzheimer’s disease
    In our preparation, we are able to follow the dynamics of microglia, i.e. the immune cells of the brain, and combine thse experiments with genetical analyses in human patient material. In this way, we hope to increase our understanding of the process of amyloid-beta clearance and the role of inflammation in Alzheimer’s disease. This project is supported by MORE (Mobility for Regional Excellence), Region VästraGötaland. Read more here: http://www.akademiliv.se/en/2013/03/10602/
  4. Neuronal networks underlying social behavior
    In collaboration with the Westberg lab at Sahlgrenska Academy, we are investigating the molecular pathways and transmitter systems underlying social behavior in mice and zebrafish. This project is supported by the Swedish Research Council, Medicine.


Principal Investigator

Petronella Kettunen

Researcher, PI



Twitter @Kettunenlab

Page Manager: Webbredaktör|Last update: 5/5/2017

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