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Neurochemistry

The goal of the neurochemical research conducted by the group is to identify protein changes representative of the pathogenic processes in various neurodegenerative diseases, such as Alzheimer’s disease and vascular dementia, so called biochemical markers. Such markers can be used to facilitate clinical diagnosis of these heterogeneous and overlapping disorders. Increased understanding of the underlying pathogenesis is possible through investigating molecular changes in the cerebrospinal fluid (CSF), a fluid mirroring biochemical processes in the brain. The combination of biochemical markers, clinical characteristics, and brain imaging gives a deeper understanding of the disease processes than each of the components alone.

In Alzheimer’s disease, tau, phosphorylated tau, and β-amyloid in the CSF are the main biomarkers used in clinical settings. Changes in β-amyloid peptides are not specific for Alzheimer’s disease, they are also to some degree found in patients with vascular dementia. The most common form of vascular dementia is subcortical vascular dementia, with changes in the white matter of the brain. White matter changes are not common in pure Alzheimer’s disease, which mainly affects the cortex. Since elevated tau in the CSF is viewed as a marker of cortical neural degeneration, and elevated neurofilaments and myelin basic protein are viewed as markers of axonal degeneration, these biomarkers are promising for use in differential diagnostics. The group currently works on finding additional biomarkers of cortical and axonal degeneration, for instance matrix metalloproteinases.

Contact Information

Anders Wallin, professor

Wallinsgatan 6, 431 41 Mölndal

Phone:
+46 (0) 31 343 10 00

News

Publications.

Illustrations: Jacob Stålhammar.

Page Manager: Webbredaktör|Last update: 1/10/2013
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