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The Alzheimer's Association multi-center study on lumbar puncture feasibility

This webpage and documents on this webpage will be updated as the program proceeds.


The CSF biomarkers tau and amyloidß (Aß) show promise as tools in the diagnostic work-up patients with suspected Alzheimer’s disease (AD) and to monitor treatment effects in AD clinical trials. However, since CSF is obtained by lumbar puncture (LP), this procedure is often avoided due to concern for complications, especially post-LP headache. Post-LP headache is strictly age-related and therefore uncommon in individuals over 60 years. A number of prospective studies on post-LP headache in patients admitted for evaluation of cognitive symptoms have also found a low incidence, below 2 %, of which most cases had only minor discomfort. Since these studies are relatively small, there is a need for a larger study on the incidence of headache and other potential complications after LP.


The aim of this study is to establish the incidence of post-LP headache and other complications in patients admitted for cognitive disturbances. The study will be powered to allow evaluation of factors influencing complications. These include factors related to both the patient (e.g. age, cognitive status, and psychological factors) and the procedure (e.g. needle type and size). Last, the study will provide data on the acceptance rate for LP.


The study is prospective. Patients admitted for clinical evaluation of cognitive disturbances, where an LP is planned as part of the diagnostic work-up, will be included. Basic patient data, details on the LP procedure, and possible complications (or absence of complications) during or after the LP are in a standardized protocol.



Data will be collected via two web based report forms. The first report form should be filled in during the patients visit and the second follow up report form within a week after the patient undergone the LP. The report forms are designed to be easy to fill in i.eg the center information needs to be filled in only once. In earlier studies, it has been found that the incidence of Post-LP complications is 2-3%. With that in mind, there is a “No complication” box in the follow up report form, that when filled in send you to the end of the form. The web based report forms can be found to the left of this page and printable versions can be found here.


To join the study, please contact Staffan Persson at NeurochemistryLab@neuro.gu.se

To download a detailed study protocol or/and a detailed study report form use this link Documents/Downloads


Kaj Blennow              Philip Scheltens          Henrik Zetterberg

MD, PhD, Professor    MD, PhD, Professor    MD, PhD, Professor



The Alz Ass LP Study NEWS


This study Is closed.

If you have questions or more patient data to enter please contact Dr. Floor Duits ( f.duits@vumc.nl ). 




Please note that this study will close 2014-03-14.
We have now decided to end the collection of patient data, and start the analysis of collected data.
We therefore wish that centers that still have data to input into the database do so before Friday, March 14.
If this is not possible please contact Staffan Persson at NeurochemistryLab@neuro.gu.se



The site that provides the report forms is currently under maintenance. Please return later to fill in the report forms.



NewsFull screen mode of the report forms available. Click the links at the web report page to open them as full screen in a new window.



On the 5th of August 2010 Kaj Blennow, together with panelists John Morris, Elaine Peskind, and Philip Scheltens, held a Webinar /Live discussion” Untapped Resource? New Study to Boost Acceptance of CSF Analysis “and the recording from that Webinar is available at:

Page Manager: Staffan Persson|Last update: 6/5/2012

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