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Regulation of Pancreatic Hormone Secretion

Principal Investigator: Patrik Rorsman

Type-2 diabetes is characterized by loss of insulin secretion from pancreatic β-cells. The reduced insulin secretion is further accompanied by defects in the release of the other islet hormones glucagon and somatostatin. The aim of our research is to explain how changes in the plasma glucose concentration, via islet cell electrical activity and increases in the cytoplasmic Ca2+-concentration, regulate exocytotic release of insulin as well as glucagon and somatostatin.

Our work involves a battery of cell physiological techniques to study secretion at the molecular, cellular and systemic levels. This requires sophisticated methodology to record the minute electrical currents flowing across biological membranes and secretion in individual cells at millisecond resolution. We also use optical techniques to monitor the movements of single secretory granules within the cell prior and during secretion.

Our studies will result in improved understanding of the fundamental processes that control pancreatic hormone secretion under physiological conditions and how they become disrupted in disease state with a view to develop new paradigms for the management and treatment of diabetes.

Photo of Patrik Rorsman

Patrik Rorsman

Principal Investigator

Phone: +46 (0)31-786 6807 or +44-1865-857348
E-mail: patrik.rorsman@gu.se eller patrik.rorsman@drl.ox.ac.uk

Visting and postal addresses

Group members

Frances Ashcroft
Guest Professor 

Lakshmi Kothegala

Nikhil Gandasi

Lisa Mellander 

Ahmed Alrifaiy

Massimo Muratore

Joana Real

Johan Tolö

Belén Chanclón García

Haiqiang Dou

Caroline Miranda
Doctoral student

Cristiano Santos
Doctoral student

Forugh Vazirisani
Biomedical analyst

Myrvete Hoti

Page Manager: Annie Sundling|Last update: 2/8/2017

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