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Developmental Neuroimmunology and Neuroinflammation


Principal Investigator: Xiaoyang Wang

Inflammation plays an important role in neonatal brain injury. Immune events triggered by microbes and by signaling from injured cells and tissues influence the generation of new lymphoid tissues, affect the differentiation of lymphocytes, and play a critical role in the development of the immune system. This in turn impacts the injury and repair processes in the developing brain.

We have shown that neonatal brain injury triggers immune responses in both the immune organs and in the brain. The central goal of our research is to identify the dynamic interactions between the developing immune system and central nervous system injury in early life as a means to develop neuroprotective therapies.

In particular, we are striving to understand the ways in which neonatal immune cells and immune responses differ from those in adults, the impact of different immune cells, the effects of inflammatory signaling molecules on central nervous system development, and the mechanisms behind injury and repair processes in the developing brain.

When genetics meet immunity - Light for cerebral palsy therapy

Neonatal brain injury in infants puts them at high risk for the development of cerebral palsy - the most common physical disability of childhood. A growing body of evidence suggests the involvement of multiple genetic factors in this process, some of which are linked to genes that regulate the inflammation that is closely associated with the development of cerebral palsy. One of the primary goals of our research is to identify the possible genetic factors that are important for the development of cerebral palsy. The discovery of genes and molecular pathways that are disrupted in cerebral palsy will help us to develop genomically guided pharmacological interventions for this disorder.

Porträttfotografi - Xiaoyang Wang

Xiaoyang Wang

Principal Investigator
M.D. Ph.D. Associate professor

Publications GUP

Contact
Phone: +46 (0)31-786 3260
xiaoyang.wang@fysiologi.gu.se
Visiting and postal addresses

Page Manager: Annie Sundling|Last update: 3/9/2017
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