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Molecular mechanisms in renal diseases


Principal Investigator: Lisa Buvall

In kidney disease the filtration barrier function is disrupted and proteins leak out from the blood into the urine. There are few treatment options today for patients with kidney disease and therefore elucidating the mechanism behind the disease is crucial in order to develop new treatment therapies.

The podocyte cell in the filtration unit of the kidney (the glomerulus) forms a characteristic interdigitating pattern with foot processes of neighboring podocytes leaving in between the filtration slits. To be able to maintain this complex architecture and kidney filtration function the podocyte is depending on its well organized actin cytoskeleton. Regulation or genetic modifications of actin regulatory proteins that causes loss of the podocyte’s actin cytoskeleton results in decreased kidney function and renal disease.

Our main focus in the group is to study the importance of actin regulatory proteins in development of renal disease to be able to find new treatment targets for patients with kidney disease.

The Podocyte | Scanning electron microgram visualising the podocyte wrapping around the capillary in the glomerulus (filtration unit in the kidney), showing the cell body (CB), major processes (MP) and foot processes (FP). Photo: Kerstin Ebefors The Podocyte | Scanning electron microgram visualising the podocyte wrapping around the capillary in the glomerulus (filtration unit in the kidney), showing the cell body (CB), major processes (MP) and foot processes (FP).

To enlarge - click on the image





Cross section of a glomerular capillary | The  selective filtration barrier is consisting of podocytes on the urinary side with their foot processes (arrows) on top of the basement membrane with fenestrated endothelial cells facing the blood hereby shown by transmission electron microgram (left) and scanning electron microgram (right). Photo: Kerstin EbeforsCross section of a glomerular capillary | The selective filtration barrier is consisting of podocytes on the urinary side with their foot processes (arrows) on top of the basement membrane with fenestrated endothelial cells facing the blood hereby shown by transmission electron microgram (left) and scanning electron microgram (right). 

To enlarge - click on the image

Pictures taken by Kerstin Ebefors.
 

 

Lisa Buvall - photo

Lisa Buvall

Principal Investigator
Assistant Professor

E-mail: lisa.buvall@neuro.gu.se
Phone: +46 (0)31-786 35 22
Visiting and postal addresses

Page Manager: Annie Sundling|Last update: 6/9/2015
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