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John-Olov Jansson

Professor

John-Olov Jansson
Professor
john-olov.jansson@medic.gu.se
+46 31 786 3526
0739-011122

Room number: 3413
Postal Address: Box 432, 40530 Göteborg
Visiting Address: Medicinaregatan 11 , 41390 Göteborg


Department of Physiology at Institute of Neuroscience and Physiology (More Information)
Box 432
405 30 Göteborg
Visiting Address: Medicinaregatan 11-13 , 413 90 Göteborg

About John-Olov Jansson

Research group
Immunometabolism Group

Teaching
Endocrinology for medical students and pharmacy students for more than 10 years. Since 2009 course leader for “BF2”, a course introducing scientific techniques and principles to medical students,

Research interest
Importance of brain components of the immune system, such as interleukin-6 (IL-6) och IL-1, for regulation of body fat.

Ongoing research / projects
We have recently found that Glucagon-like peptide-1 (GLP-1) suppresses body fat mass via interleukin-6 (IL-6) in the brain. This is a great interest since we have long-term interest in the metaolic of IL-6 and since GLP-1 analogues, such as exendin-4 (Byetta sand Bydureon) and liraglutide (Victoza and Saxenda) are widely used for treatment of type 2 diabetes and obesity. Surprisingly little has been known about the mechanism of action of this important group of drugs.

Related publications (PubMed):


 

Latest publications

Disentangling the genetics of lean mass
D. Karasik, M. C. Zillikens, Y. H. Hsu, A. Aghdassi, K. Akesson et al.
American Journal of Clinical Nutrition, Journal article 2019
Journal article

Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver.
Yuehui Zhang, Fanci Meng, Xiaoyan Sun, Xue Sun, Min Hu et al.
Oncotarget, Journal article 2018
Journal article

Body weight homeostat that regulates fat mass independently of leptin in rats and mice.
John-Olov Jansson, Vilborg Palsdottir, Daniel Hägg, Erik Schéle, Suzanne L. Dickson et al.
Proceedings of the National Academy of Sciences of the United States of America, Journal article 2018
Journal article

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate
I. R. Botusan, X. Zheng, S. Narayanan, J. Grünler, V. G. Sunkari et al.
PLoS ONE, Journal article 2018
Journal article

Reply to Lund: Where does the gravitostat fit in?
Claes Ohlsson, John-Olov Jansson
Proceedings of the National Academy of Sciences of the United States of America, Journal article 2018
Journal article

Showing 51 - 60 of 99

2010

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Elizabeth K Speliotes, Cristen J Willer, Sonja I Berndt, Keri L Monda, Gudmar Thorleifsson et al.
Nature genetics, Journal article 2010
Journal article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Iris M Heid, Anne U Jackson, Joshua C Randall, Thomas W Winkler, Lu Qi et al.
Nature genetics, Journal article 2010
Journal article

Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
Thomas J Wang, Feng Zhang, J Brent Richards, Bryan Kestenbaum, Joyce B van Meurs et al.
Lancet, Journal article 2010
Journal article

2009

Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men.
Niklas Andersson, Louise Strandberg, Staffan Nilsson, Ö Ljungren, Magnus K Karlsson et al.
International journal of obesity (2005), Journal article 2009
Journal article

A missense mutation in the non-neural G-protein alpha-subunit isoforms modulates susceptibility to obesity.
M L Kelly, L Moir, L Jones, E Whitehill, Q M Anstee et al.
International journal of obesity , Journal article 2009
Journal article

Showing 51 - 60 of 99

Page Manager: Annie Sundling|Last update: 5/6/2015
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