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John-Olov Jansson

Professor

John-Olov Jansson
Professor
john-olov.jansson@medic.gu.se
+46 31 786 3526
0739-011122

Room number: 3413
Postal Address: Box 432, 40530 Göteborg
Visiting Address: Medicinaregatan 11 , 41390 Göteborg


Department of Physiology at Institute of Neuroscience and Physiology (More Information)
Box 432
405 30 Göteborg
Visiting Address: Medicinaregatan 11-13 , 413 90 Göteborg

About John-Olov Jansson

Research group
Immunometabolism Group

Teaching
Endocrinology for medical students and pharmacy students for more than 10 years. Since 2009 course leader for “BF2”, a course introducing scientific techniques and principles to medical students,

Research interest
Importance of brain components of the immune system, such as interleukin-6 (IL-6) och IL-1, for regulation of body fat.

Ongoing research / projects
We have recently found that Glucagon-like peptide-1 (GLP-1) suppresses body fat mass via interleukin-6 (IL-6) in the brain. This is a great interest since we have long-term interest in the metaolic of IL-6 and since GLP-1 analogues, such as exendin-4 (Byetta sand Bydureon) and liraglutide (Victoza and Saxenda) are widely used for treatment of type 2 diabetes and obesity. Surprisingly little has been known about the mechanism of action of this important group of drugs.

Related publications (PubMed):


 

Latest publications

Disentangling the genetics of lean mass
D. Karasik, M. C. Zillikens, Y. H. Hsu, A. Aghdassi, K. Akesson et al.
American Journal of Clinical Nutrition, Journal article 2019
Journal article

Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver.
Yuehui Zhang, Fanci Meng, Xiaoyan Sun, Xue Sun, Min Hu et al.
Oncotarget, Journal article 2018
Journal article

Body weight homeostat that regulates fat mass independently of leptin in rats and mice.
John-Olov Jansson, Vilborg Palsdottir, Daniel Hägg, Erik Schéle, Suzanne L. Dickson et al.
Proceedings of the National Academy of Sciences of the United States of America, Journal article 2018
Journal article

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate
I. R. Botusan, X. Zheng, S. Narayanan, J. Grünler, V. G. Sunkari et al.
PLoS ONE, Journal article 2018
Journal article

Reply to Lund: Where does the gravitostat fit in?
Claes Ohlsson, John-Olov Jansson
Proceedings of the National Academy of Sciences of the United States of America, Journal article 2018
Journal article

Showing 41 - 50 of 99

2011

Genetic Association and Gene Expression Analysis Identify FGFR1 as a New Susceptibility Gene for Human Obesity.
Hong Jiao, Peter Arner, Suzanne L. Dickson, Hubert Vidal, Niklas Mejhert et al.
The Journal of clinical endocrinology and metabolism, Journal article 2011
Journal article

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
Tuomas O Kilpeläinen, Lu Qi, Soren Brage, Stephen J Sharp, Emily Sonestedt et al.
PLoS medicine, Journal article 2011
Journal article

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
Tuomas O Kilpeläinen, M Carola Zillikens, Alena Stančákova, Francis M Finucane, Janina S Ried et al.
Nature genetics, Journal article 2011
Journal article

Genetic determinants of serum testosterone concentrations in men.
Claes Ohlsson, Henri Wallaschofski, Kathryn L Lunetta, Lisette Stolk, John R B Perry et al.
PLoS genetics, Journal article 2011
Journal article

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
Elizabeth K Speliotes, Laura M Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J Kim et al.
PLoS genetics, Journal article 2011
Journal article

2010

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance.
V B Matthews, T L Allen, S Risis, M H S Chan, D C Henstridge et al.
Diabetologia, Journal article 2010
Journal article

Showing 41 - 50 of 99

Page Manager: Annie Sundling|Last update: 5/6/2015
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