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John-Olov Jansson

Professor

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John-Olov Jansson
Professor
john-olov.jansson@medic.gu.se
+46 31 786 3526
0739-011122

Room number: 3413
Postal Address: Box 432, 40530 Göteborg
Visiting Address: Medicinaregatan 11 , 41390 Göteborg


Department of Physiology at Institute of Neuroscience and Physiology (More Information)
Box 432
405 30 Göteborg
Visiting Address: Medicinaregatan 11-13 , 413 90 Göteborg

About John-Olov Jansson

Research group
Immunometabolism Group

Teaching
Endocrinology for medical students and pharmacy students for more than 10 years. Since 2009 course leader for “BF2”, a course introducing scientific techniques and principles to medical students,

Research interest
Importance of brain components of the immune system, such as interleukin-6 (IL-6) och IL-1, for regulation of body fat.

Ongoing research / projects
We have recently found that Glucagon-like peptide-1 (GLP-1) suppresses body fat mass via interleukin-6 (IL-6) in the brain. This is a great interest since we have long-term interest in the metaolic of IL-6 and since GLP-1 analogues, such as exendin-4 (Byetta sand Bydureon) and liraglutide (Victoza and Saxenda) are widely used for treatment of type 2 diabetes and obesity. Surprisingly little has been known about the mechanism of action of this important group of drugs.

Related publications (PubMed):


 

CV

Research areas

Latest publications

Dietary Polyunsaturated Fatty Acids Promote Neutrophil Accumulation in the Spleen by Altering Chemotaxis and Delaying Cell Death
Sara L Svahn, Saray Gutiérrez, Marcus A Ulleryd, I. Nookaew, Veronica Osla et al.
Infection and Immunity, Journal article 2019
Journal article

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on a web page

Interleukin-6 in the central amygdala is bioactive and co-localised with glucagon-like peptide-1 receptor
Fredrik Anesten, Adria Dalmau Gasull, Jennifer E. Richard, Imre Farkas, Devesh Mishra et al.
Journal of Neuroendocrinology, Journal article 2019
Journal article

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on a web page

Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body Weight
Vilborg Palsdottir, Sara H Windahl, Daniel Hägg, Hanna Keantar, Jakob Bellman et al.
Endocrinology, Journal article 2019
Journal article

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on a web page

Disentangling the genetics of lean mass
D. Karasik, M. C. Zillikens, Y. H. Hsu, A. Aghdassi, K. Akesson et al.
American Journal of Clinical Nutrition, Journal article 2019
Journal article

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on a web page

Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver.
Yuehui Zhang, Fanci Meng, Xiaoyan Sun, Xue Sun, Min Hu et al.
Oncotarget, Journal article 2018
Journal article

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on a web page

Body weight homeostat that regulates fat mass independently of leptin in rats and mice.
John-Olov Jansson, Vilborg Palsdottir, Daniel Hägg, Erik Schéle, Suzanne L. Dickson et al.
Proceedings of the National Academy of Sciences of the United States of America, Journal article 2018
Journal article

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on a web page

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate
I. R. Botusan, X. Zheng, S. Narayanan, J. Grünler, V. G. Sunkari et al.
PLoS ONE, Journal article 2018
Journal article

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on a web page

Reply to Lund: Where does the gravitostat fit in?
Claes Ohlsson, John-Olov Jansson
Proceedings of the National Academy of Sciences of the United States of America, Journal article 2018
Journal article

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on a web page

The Gravitostat Regulates Fat Mass in Obese Male Mice While Leptin Regulates Fat Mass in Lean Male Mice
Claes Ohlsson, Daniel Hägg, Fredrik Hammarhjelm, Adria Gasull, Jakob Bellman et al.
Endocrinology, Journal article 2018
Journal article

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on a web page

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
M. C. Zillikens, S. Demissie, Y. H. Hsu, L. M. Yerges-Armstrong, W. C. Chou et al.
Nature Communications, Journal article 2017
Journal article

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on a web page

Showing 21 - 30 of 98

2016

Female Mice Lacking Estrogen Receptor-alpha in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass
Helen H. Farman, Sara H Windahl, Lars Westberg, H. Isaksson, Emil Egecioglu et al.
Endocrinology, Journal article 2016
Journal article

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on a web page

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Tuomas O. Kilpeläinen, Jayne F. Martin Carli, Alicja A. Skowronski, Qi Sun, Joel Eriksson et al.
Nature Communications, Journal article 2016
Journal article

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on a web page

Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6
Fredrik Anesten, M. K. Holt, Erik Schéle, Vilborg Palsdottir, F. Reimann et al.
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, Journal article 2016
Journal article

Regulation of body fat mass by the gut microbiota: Possible mediation by the brain.
Erik Schéle, Louise Grahnemo, Fredrik Anesten, Anna Hallén, Fredrik Bäckhed et al.
Peptides, Review article 2016
Review article

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on a web page

2015

Dietary polyunsaturated fatty acids increase survival and decrease bacterial load during septic S. aureus infection, and improve neutrophil function in mice
Sara L Svahn, Louise Grahnemo, Vilborg Palsdottir, Intawat Nookaew, Karl Wendt et al.
Infection and Immunity, Journal article 2015
Journal article

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on a web page

The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice.
Johan Bourghardt Fagman, Anna S K Wilhelmson, Benedetta Maria Motta, Carlo Pirazzi, Camilla Alexanderson et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2015
Journal article

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on a web page

Brain IL-6--Where Amylin and GLP-1 Antiobesity Signaling Congregate.
John-Olov Jansson, Vilborg Palsdottir
Diabetes, Magazine article 2015
Magazine article

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on a web page

Ghrelin.
T D Müller, R Nogueiras, M L Andermann, Z B Andrews, S D Anker et al.
Molecular metabolism, Journal article 2015
Journal article

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on a web page

2014

GLP-1 Receptor Stimulation of the Lateral Parabrachial Nucleus Reduces Food Intake: Neuroanatomical, Electrophysiological, and Behavioral Evidence
Jennifer E. Richard, I. Farkas, Fredrik Anesten, Rozita H Anderberg, Suzanne L. Dickson et al.
Endocrinology, Journal article 2014
Journal article

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on a web page

2013

The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system.
Erik Schéle, Louise Grahnemo, Fredrik Anesten, Anna Hallén, Fredrik Bäckhed et al.
Endocrinology, Journal article 2013
Journal article

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on a web page

Showing 21 - 30 of 98

Page Manager: Annie Sundling|Last update: 5/6/2015
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