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Membrane transporters in drug disposition

We study the role of membrane transporters in the absorption, cellular uptake, tissue distribution and elimination of drug molecules. A particular focus is on the molecular mechanisms of transporter-mediated drug interactions and -translocation.

Crystal structure of the human glucose transporter GLUT1 with glucose bound.Hundreds of distinct proteins mediate transport of small-molecule solutes across biological membranes. These include the members of the ATP-Binding Cassette (ABC) and Solute Carrier (SLC) protein superfamilies, of which currently a couple of dozens have demonstrated roles in the disposition of drug molecules.

Many questions concerning drug transporters remain unanswered, including which of all transporters are relevant for drug-like molecules, how these are expressed, regulated and dynamically presented in human tissues, and what the molecular properties of drug molecules are that lead to their binding to the transporter, their translocation, and/or to transporter mediated drug–drug interactions? We use a combination of in vitro measurements and computational modeling techniques to address such questions.

Contact information

Pär Matsson

E-mail: par.matsson@gu.se

Page Manager: Webbredaktör|Last update: 12/12/2019

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