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Intracellular drug exposure

We use computational and experimental methods to simulate, quantitate and visualize drug distribution at the tissue, cellular and subcellular scales.

Most pharmacologically interesting proteins are located in the cell interior. Consequently, drug concentrations at intracellular or subcellular sites are driving the pharmacological and toxicological actions of the majority of drugs. Together with the Per Artursson lab at Uppsala University we have developed an assay that allows mass spectrometric measurements of unbound intracellular drug concentrations, i.e., the drug concentration that is available to interact with intracellular targets. We are now exploring the use of this methodology for new classes of drug molecules, in combination with other biophysical measurements, imaging techniques and computational modeling and simulation, to understand the mechanisms of intracellular drug distribution and the connection to cellular pharmacology.

Fluorescence imaging of drug distribution in cultured human cells.

Fluorescence imaging of drug distribution in cultured human cells.

Contact information

Pär Matsson

E-mail: par.matsson@gu.se

Page Manager: Webbredaktör|Last update: 12/12/2019

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