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Prediction of human pharmacokinetic properties of drugs under development

Pharmacokinetic studies are conducted in early drug development for selection of potential drug candidates. One of the greatest challenges is to predict a compound´s human  pharmacokinetics based on data available from preclinical studies. 

Physiologically-based pharmacokinetic (PBPK) models offer a powerful tool to scale-up and predict pharmacokinetics in man. PBPK models map the complex drug transport scheme onto a physiologically realistic compartmental structure. PBPK models also allow the prediction of specific tissue concentrations not possible in conventional pharmacokinetic modeling.


PBPK models require a number of parameters which can be divided into physiological and drug-specific parameters.
A conventional drawback with PBPK modeling is the time-consuming effort to determine the drug-specific parameters such as the equilibrium tissue-to-plasma concentration ratios. We therefore seek to develop models which may predict some of the drug-specific parameters. We use a combination of standard animal pharmacokinetic data (volume of distribution, clearance etc) in combination with the physicochemical properties of a compound to obtain reliable drug-specific parameters for inclusion in PBPK models. 
 

 

 

Contact Information

Michael Ashton

Box 431 , 405 30 Göteborg

Visiting Address:
Medicinaregatan 13A

Phone:
+46 (0)31 786 34 12

Fax:
+46 (0)31 786 32 84

Page Manager: Webbredaktör|Last update: 3/13/2009
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