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Pharmacokinetics and Drug Metabolism

Research at the unit encompasses pharmacokinetic, metabolic, toxicological and pharmacodynamic studies of small molecules as well as non-traditional synthetic and biological drugs.

Research projects range from clarifying molecular mechanisms of drug disposition, via translational studies using in vitro tools and computational modeling, to clarifying the clinical disposition and efficacy of drugs in specific human populations.

Research in the Ashton group

The overall objective is to obtain such pharmacokinetic, metabolic, toxicological and pharmacodynamic information on  drugs as to enable recommendation of safe and effiacious future treatments with a particular focus on poverty-related infections.

The following competencies are available

  • Quantitation of drugs and metabolites in biological matrices (HPLC/UV/fluorescence/RAD; LC/MS/MS)
  • Modelling and simulation; population PKPD, PBPK
  • Enzyme inhibition studies; in vitro and in vivo
  • Non-clinical and clinical in vivo pharmacokinetics
  • Intestinal drug absorption (Ussing chamber)
  • Drug plasma protein binding studies

Projects

Contact information

Michael Ashton, Professor

Tel +46 (0)31 786 34 12
Fax +46 (0)31 786 32 84

E-mail: michael.ashton@gu.se

Research in the Matsson group

Our research aims to clarify molecular and cellular mechanisms of drug disposition through a combination of wet-lab experiments and computational modeling and simulation. We particularly focus on disposition mechanisms and intracellular exposure of new drug modalities, and development of methodologies to study this in vitro and in silico.

Projects

Contact information

Pär Matsson
Professor

E-mail: par.matsson@gu.se

Page Manager: Webbredaktör|Last update: 12/12/2019
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