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PKDM News

PKDM welcomes professor Pär Matsson

[September 3, 2019] Professor Pär Matsson started at Department of Pharmacology, Sahlgrenska Academy in September 2019. Dr. Pär Matsson has published over 30 scientific articles and has contributed to the field of pharmacokinetics and drug disposition investigating the role of drug transporters.

PKDM welcomes senior lecturer Sofia Birgersson

[September 3, 2019] It is with great pleasure PKDM announces the return of Dr. Sofia Birgersson to the Department of Pharmacology who will initiate her role as senior lecturer in September 2019.

PKDM welcomes PhD student Emma Johansson

[September 3, 2019] Emma Johansson will start her doctoral studies at PKDM. Emma Johansson has been recruited to investigate the pharmacokinetics and drug disposition of N,N-dimethyltryptamine (DMT), an endogenous serotonergic compound, which potentially could be used to treat various psychiatric conditions.

PhD studentship open for application

[November 7th, 2018]

PKDM Unit is currently recruiting a new PhD candidate to study PKPD relationships of psychedelic compounds. Deadline: Nov 28th, 2018.

Focus will be on N,N-dimethyltryptamine (DMT), an endogenous serotonergic compound. It is currently being investigated elsewhere as a therapeutic agent in the treatment or amelioration of a number of psychiatric conditions such as post-traumatic stress disorders, depression and end-of-life anxiety. Its disposition in the human body is virtually unknown. This PhD project entails approx. 4-5 years of research interloped with one year of teaching contributions in the areas of pharmacokinetics, drug metabolism and pharmacodynamics for MSc(Pharm) and BSc (Pharm) student. The full duration is thus four to five years.

Relocation

In November 2018 Dr Sofia Birgersson joined AstraZeneca R&D DMPK/CVRM. With many thanks for her contributions to the PKDM Unit not the least establishing our LC-MS/MS lab, we wish her godspeed in her professional future.

Dissertation Mohd Yusmaidie Aziz

On October 23rd, 2017, Mohd Yusmaidie Aziz defended his doctoral thesis “Piperaquine and Metabolites – Bioanalysis and Pharmacokinetics”.

Faculty opponent was Professor Hege Christensen from the Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Norway.

Dissertation Sofia Birgersson

On September 25th 2015 Sofia Birgersson defended her doctoral thesis Pharmacokinetics of artemisinin derivatives in rats, healthy volunteers and patients. Faculty opponent was Professor Kevin Batty, School of Pharmacy, Curtin University, Perth, Australia.


Degree project student awarded price

Lisa Olsson was awarded a scholarship from the Swedish Pharmaceutical Society for her master thesis, which was found to be one of the three best theses within the 5-year programme in pharmacy leading to MSc (Pharm) degree at the University of Gothenburg this year.

Title of the thesis: “Population pharmacokinetic modelling of drug-drug interactions between antiretroviral and antimalarial drugs in HIV-infected patients in Uganda”.

Principal / Co-supervisor: Angela Äbelö/ Richard Höglund

New Lecturer

We are pleased to announce that Dr Elin Karlsson has joined the group as Senior Lecturer in Drug Metabolism. Dr Karlsson was awarded a PhD at the University of Manchester in 2008 with Professor Brian Houston as supervisor. This was followed by a post-doc position at AstraZeneca R&D Alderley Park. She then worked as Senior Lecturer in Pharmacology at University of Central Lancashire, in Preston, UK, before obtaining a post-doc position at AstraZeneca R&D Södertälje. Joining the PKDM group in August, she returns to the university where she received her basic training (MPharm). Dr Karlsson’s research interests are in the area of phase II metabolism, especially the use of in vitro methods in the prediction of glucuronidation kinetics and extrapolation of in vitro clearance by phase II metabolising enzymes to in vivo.

PKDM Group Receives International Recognition

[August/September 2012 ]In a recent commentary published in the British Journal of Clinical Pharmacology, Prof Geoffrey T Tucker (SimCyp Ltd, Sheffield, UK) identifies the University of Gothenburg as a place of global excellence for training in pharmacokinetics.
We quote from the paper:

Where are the academic centres?

Good pharmacokineticists are born, but they also need training. Currently, the global centres with the highest profiles for providing in-depth training include Departments of Pharmaceutical Science in the Universities of Buffalo, Florida, Gothenburg, Leiden, Otago, San Francisco, Tokyo, Uppsala and Washington. In the UK, the Universities of Manchester (Pharmaceutical Sciences) and Sheffield (Clinical Pharmacology) in particular have been recognized internationally as centres of pharmacokinetic excellence.”

Reference: Tucker GT, Research priorities in pharmacokinetics, BJCP 2012; 73(6): 924-6
 

 

October 2011:

Award for ‘Most Informative Scientific Report’


Our recent paper in British Journal of Clinical Pharmacology ‘In silico prediction of efavirenz and rifampacin drug-drug interaction considering weight and CYP2B6 phenotype’ has been awarded the Annual Simcyp Academic IVIVE Awards’ for ‘Most Informative Scientific Report’.

The annual awards recognise cutting-edge published research in the fields of in vitro – in vivo extrapolation (IVIVE), ADME, pharmaceutics and modelling and simulation. In this paper we utilize in vitro in vivo extrapolation techniques to answer the specific question of whether or not to increase the efavirenz dose based on body weight when the patients is co-medicated with rifampicin. The results from this simulation suggests that increasing the efavirenz dose may be appropriate only in patients with body weight over 50 kg.
For more information about the award and our publication please visit the following sites:

simcyp

Sahlgrenska academy (swedish)

PubMed

Picture: Dinko Rekić received the award by Professor Brian Houston at the annual SimCYP consortium meeting in Sheffield, UK.

 

 

October 2010:

 

“Most Innovative Teaching Application”-award

 

The PKDM Unit has been awarded the Simcyp (www.simcyp.com) ‘Most Innovative Teaching Application’ accolade 2010 for a newly developed students’ exercise on in vitro – in vivo extrapolation. The exercise is since February 2010 part of the elective course on “Preclinical drug development: drug metabolism and in vitro - in vivo prediction” offered in the 5-year Pharmacy programme at the University of Gothenburg (FAB820). The students conduct a drug inhibition assay with recombinant CYP3A4, estimate inhibition constants (IC50) by modelling in WinNonlin software and simulate a drug-drug interaction using the Simcyp Population-based Simulator. Thus the exercise encompasses “wet” experimental work, parameter estimation by non-linear regression and advanced
simulation with state-of-the-art software illustrating the potential of using preclinical in vitro data to predict clinical drug-drug interaction potential.
Dinko Rekić received the award on behalf of the Unit from Professor Malcolm Rowland, Chair of Simcyp’s Scientific Advisory Board, at the 11th Annual Simcyp Consortium Meeting on September 20th in Sheffield, UK.
 

 

 



Dr Kurt-Jürgen Hoffmann, former Senior Principal Scientist at AstraZeneca R&D Mölndal, has this year joined the Unit as consultant. Dr Hoffmann contributes with his vast experience in mass spectrometry and drug metabolite identification.

Dr Angela Äbelö has since June taken up her position as Senior Lecturer in Pharmacokinetics and Pharmacodynamics at the Unit. Dr Äbelö comes from a position as pharmacometrian at AstraZeneca R&D.

 

 

Contact Information

Michael Ashton

Box 431 , 405 30 Göteborg

Visiting Address:
Medicinaregatan 13A

Phone:
+46 (0)31 786 34 12

Fax:
+46 (0)31 786 32 84

Page Manager: Webbredaktör|Last update: 9/3/2019
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