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Neurotoxicity in cancer survivors

Principal Investigator: Marie Kalm

Thanks to improved treatment strategies in the fight against cancer in the brain, we now see an increase in long-term survivors. The price for survival is however high and the survivors have a life-time to repay. Cognition is one of the most important brain functions that is impaired, mainly by cranial radiotherapy. The mechanisms leading to the cognitive decline is not fully understood, as well as how it can be prevented. Our group is studying different radiation-induced side effects with the overall goal of reducing the prevalence and severity of brain dysfunction.

Our continued work includes both clinical and preclinical studies. Can biomarkers be used to foresee the individual’s path toward a chronic neurodegenerative state following cranial radiotherapy? We are currently investigating radiation-induced injury processes in relation to the individual sensitivity to radiotherapy towards the brain in both adult and pediatric patients. Also, we have ongoing preclinical experiments that are investigating protective effects using pharmaceuticals that modulate the chemical milieu after cranial radiotherapy.

Porträttfoto - Marie Kalm

Marie Kalm

Principal Investigator

Phone: +46 31-786 3425
E-mail: marie.kalm@gu.se


Group members

Martina Boström, PhD, Postdoc

Erik Fernström, MD, doctoral student

Yohanna Eriksson, MSc

Rita Grandér, BMA

Page Manager: Webbredaktör|Last update: 9/16/2016

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