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Pär Matsson

Professor

Pär Matsson
Professor
par.matsson@gu.se

Postal Address: Box 431, 40530 Göteborg
Visiting Address: Medicinaregatan 11-13 , 41390 Göteborg


Department of Pharmacolgy at Institute of Neuroscience and Physiology (More Information)
Box 431
405 30 Göteborg
www.neurophys.gu.se/sektioner
farmakologi@gu.se
Fax: +46 31821795
Visiting Address: Medicinaregatan 11-13 , 413 90 Göteborg

About Pär Matsson

Research in the Matsson group

Our research aims to clarify molecular and cellular mechanisms of drug disposition through a combination of wet-lab experiments and computational modeling and simulation. We particularly focus on disposition mechanisms and intracellular exposure of new drug modalities, and development of methodologies to study this in vitro and in silico.

Projects

 

Latest publications

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids
A. Treyer, A. Mateus, J. R. Wisniewski, H. Boriss, Pär Matsson et al.
Mol Pharm, Journal article 2018
Journal article

Molecular Modeling of Drug-Transporter Interactions-An International Transporter Consortium Perspective
A. Schlessinger, M. A. Welch, H. van Vlijmen, K. Korzekwa, P. W. Swaan et al.
Clin Pharmacol Ther, Review article 2018
Review article

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5
M. Rossi Sebastiano, B. C. Doak, M. Backlund, V. Poongavanam, B. Over et al.
J Med Chem, Journal article 2018
Journal article

Erratum: Structural and conformational determinants of macrocycle cell permeability
B. Over, Pär Matsson, C. Tyrchan, P. Artursson, B. C. Doak et al.
Nat Chem Biol, Journal article 2017
Journal article

How Big Is Too Big for Cell Permeability?
Pär Matsson, J. Kihlberg
J Med Chem, Review article 2017
Review article

Intracellular drug bioavailability: a new predictor of system dependent drug disposition
A. Mateus, A. Treyer, C. Wegler, M. Karlgren, Pär Matsson et al.
Sci Rep, Journal article 2017
Journal article

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery
A. Mateus, L. J. Gordon, G. J. Wayne, H. Almqvist, H. Axelsson et al.
Proc Natl Acad Sci U S A, Journal article 2017
Journal article

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9
I. Simoff, M. Karlgren, M. Backlund, A. C. Lindstrom, F. Z. Gaugaz et al.
J Pharm Sci, Journal article 2016
Journal article

Showing 1 - 10 of 33

2019

2018

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids
A. Treyer, A. Mateus, J. R. Wisniewski, H. Boriss, Pär Matsson et al.
Mol Pharm, Journal article 2018
Journal article

Molecular Modeling of Drug-Transporter Interactions-An International Transporter Consortium Perspective
A. Schlessinger, M. A. Welch, H. van Vlijmen, K. Korzekwa, P. W. Swaan et al.
Clin Pharmacol Ther, Review article 2018
Review article

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5
M. Rossi Sebastiano, B. C. Doak, M. Backlund, V. Poongavanam, B. Over et al.
J Med Chem, Journal article 2018
Journal article

2017

Erratum: Structural and conformational determinants of macrocycle cell permeability
B. Over, Pär Matsson, C. Tyrchan, P. Artursson, B. C. Doak et al.
Nat Chem Biol, Journal article 2017
Journal article

How Big Is Too Big for Cell Permeability?
Pär Matsson, J. Kihlberg
J Med Chem, Review article 2017
Review article

Intracellular drug bioavailability: a new predictor of system dependent drug disposition
A. Mateus, A. Treyer, C. Wegler, M. Karlgren, Pär Matsson et al.
Sci Rep, Journal article 2017
Journal article

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery
A. Mateus, L. J. Gordon, G. J. Wayne, H. Almqvist, H. Axelsson et al.
Proc Natl Acad Sci U S A, Journal article 2017
Journal article

2016

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9
I. Simoff, M. Karlgren, M. Backlund, A. C. Lindstrom, F. Z. Gaugaz et al.
J Pharm Sci, Journal article 2016
Journal article

Showing 1 - 10 of 33

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