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Research Areas

 

The group of researcher works within the following areas and uses a big number of models from cells, zebrafish and mice to clinical studies on patients and healthy volunteers:

 

Diagnostics, like diagnostic markers för neurodegenerative diseases, for example Alzheimer. We have during the last 10 years developed methods to determine tau, phospo-tau and b-amyloid in cerebro-spinal fluid (CSF), which today is used in the clinic. The aim is to further develop these analyses and to find more diagnostic markers.

Theragnostics, as a means to identify and monitor the biochemical effect of new treatment methods. To evaluate the clinical effect of new drugs for i.e. Alzheimer demands large case of patients and long time of treatment, while a biochemical effect might be identified in the CSF on a smaller number of patients and after shorter time of treatment.

Pathogenesis, studies of the pathogenesis of diseases, that is to study in detail biochemical changes in living patients with neurodegenerative diseases. Changes in biochemical markers can be correlated to clinical characteristics, changes in brain imaging, and known and potential susceptibility genes.


Two main principles will be followed:

 

  • Candidate markers, that is biochemical markers for known pathogenetic processes in neurodegenerative diseases. One example of this is tau protein as a marker for neuronal degeneration and b-amyloid for senile plaques of Alzheimer. Example of a potential candidate marker is a-synuclein of Parkinson’s disease.

 

  • Proteomics, that is different combinations of protein separation methods (2-D electroforesis, protein chips, nano-LC) and mass spectrometry (MALDI-TOF MS; ESI-Q-FT-ICR MS). The aim of proteomic is to study as many proteins (proteomes) as possible, and by comparing between for instance sick-healthy and before-after treatment, identify new changes in proteins.

 

Page Manager: Staffan Persson|Last update: 6/2/2010
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