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The aetiology and pathophysiology of Parkinson's disease

Gene mutations in some specific genes have been shown to cause rare familial Parkinson’s disease (PD). For sporadic PD, with no marked familial aggregation, which accounts for at least 90% of all cases, the causes for the cell degeneration are unknown. Several environmental factors have been suggested to be of importance, however, not yet has any single or cluster of factors unequivocally been shown to cause sporadic Parkinson disease.

The aim of the project is to find genes and environmental factors that are of importance for the aetiology/pathogenesis of PD. Ongoing subprojects are; 1) to reveal causing mutations in two separate families with autosomal dominantly inherited PD, 2) to find susceptibility genes of importance for the pathophysiology of sporadic PD, 3) to investigate if infection with certain neurotrophic virus of can be associated with sporadic PD, 4) by using Swedish Military Service Conscription Registry investigate whether motor performance in PD patients is affected already in early age, long before manifest symptoms appear.

Hans Nissbrandt

Professor, Principal investigator

Phone: +46 31-786 34 26

E-mail: hans.nissbrandt@pharm.gu.se

Research group members

Hans Nissbrandt
Professor

Camilla Fardell
PhD student

Page Manager: Lennart Svensson|Last update: 9/7/2016
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